Univercells Technologies NevoLine™ Upstream Platform
Watch the Video
Learn how the NevoLine™ Upstream platform accommodates all unit operations from inoculation to midstream processing within a compact module in the video above. Single-use assemblies can be selected and combined to meet your process requirements.
Single Automation System
With automated recipe execution from cell culture to final clarification, our NevoLine™ Upstream platform features:
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- In-line process control and monitoring
- Single, intuitive HMI for comprehensive system operation
- Recipe configurator to quickly start manufacturing
Overview
The NevoLine™ Upstream platform is an innovative biomanufacturing technology that delivers cost-effective viral production. The high-performance, intensified platform features a flexible design to accommodate viral vaccines, gene therapies, and oncolytic virus production. With the NevoLine™ Upstream platform, automated GMP clinical and commercial-scale upstream production is achieved within a 3 m² footprint.
Features and Benefits
- Large-scale capacity in a compact module
- Commercial-scale throughput in a 3 m² footprint
- Integration of the intensified scale-X™ nitro bioreactor delivering high cell density
- Total Growth Area: 200 m2 OR 600 m2
- Reliable operations for reproducible performance
- Process automation reducing the number of manual interventions and minimizing risk of human error
- Seamless scalability achieved via the scale-X bioreactor structured fixed-bed design
- Rapid manufacturing start-up
- Ergonomic design easing installation and in-process activities
- Continuous processing within a single automated system reducing production time
- Ergonomic compact upstream module – A single hardware designed to fit most process specificities and ease manipulations within a controlled microenvironment
- Plug & play platform for easy installation and operation
- Uni-directional air flow cabinet
- Integrated HVAC and electrical connections
Documents
Applications
- Adenovirus
- Lentivirus
- AAV
- Viral vaccine production
- Gene therapy
- Oncolytic viruses
- Clinical and commercial manufacturing
- Upstream and midstream processing of viral products
Product Comparison
Univercells Technologies
Nevo Upstream Platform
- Available in 200 and 600 m² of fixed bed surface area
- Single or multi-step clarification
- In-line or batch TFF
- Combines single-use assemblies and process specific configurations
- Commercial scale GMP production in a 3 meters² footprint
Univercells Technologies scale-X hydro Bioreactor
- Available in 2.4 m² of fixed bed surface area
- Automated process control
- Monitors and adjusts pH, DO, temperature and agitation
- Built-in peristaltic pumps
- Pre-assembled tubing manifolds available
Univercells Technologies scale-X carbo Bioreactor
- Available in 10 and 30 m² of fixed bed surface area
- Automated process control
- Docking slots available for single-use components
- Sensors for pH, DO, temperature, pressure, and fluid levels
- Quick access screen
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